Michael B.A. Oldstone, MD
Professor, Immunology & Microbiology, Scripps Research
Michael B.A. Oldstone is a Professor in the Department of Immunology & Microbiology at Scripps Research where he heads the Viral-Immunobiology Laboratory. He focuses on viral-host interactions, especially how viruses cause disease. His work studying the prototype arenavirus lymphocytic choriomeningitis virus dissected the biologic and molecular parameters of how virus infection leads to the submission or the enhancement of the immune response. Submission or subversion leads to viral persistence and enhancement to autoimmunity and immunopathology. Using experimental animal model systems, his findings, especially with virus-specific cytotoxic T cells, with molecules that negatively regulate such cytotoxic T cells and with formation and consequences of viral antibody immune complexes, have been extended to infectious diseases of humans. These paradigm observations, coupled with his work on viral variants and dendritic cell interactions have led to his election to the National Academy of Sciences, the Institute of Medicine of the National Academy of Sciences, and numerous international and national scientific awards and honors. He also served as a consultant to the World Health Organization Scientific Advisory Group of Experts and as a consultant for the eradication of poliomyelitis and measles viruses.