VHFC Investigators take part in 11th Annual ASM Biodefense and Emerging Diseases Research Meeting

Scientists from Tulane and Harvard University took part in the 2013 ASM Biodefense and Emerging Diseases Research Meeting held on February 25-27 in Washington D.C. The event featured talks by Dr. Jennifer Spence (School of Medicine, Tulane University) and Dr.

Publication - Lassa fever: why there are more public health questions than answers

In an article published in The Guardian, VHFC Scientist Dr. Lina Moses discusses her research into the Mastomys rodents that transmit Lassa fever and how novel approaches to rodent control are being used to combat the disease on a local level.

The Virus Hunter - Erica Ollmann Saphire featured in U-T San Diego

A recent article in U-T San Diego features structural biologist and VHFC researcher Erica Ollmann Saphire. The article discusses her career path and research into the structures of virus-related proteins such as Lassa and Ebola.

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Publication - A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection.

VHFC scientists were able to locate three persons who worked in Nigeria dating back to the 1940s, two of whom were integrally involved in the early outbreaks and investigations of Lassa fever in the late 1960s, including the person from whom Lassa virus was first isolated.

Pardis Sabeti - the rollerblading rock star scientist of Harvard

VHFC scientist Pardis Sabeti, the recipient of the Smithsonian American Ingenuity Award for natural sciences, was recently featured in an article on

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VHFC Investigators present promising data on Lassa fever diagnostics

At the 61st annual meeting of The American Society of Tropical Medicine and Hygiene (ASTMH) researchers from VHFC and Corgenix reported on their findings using ELISA-based diagnostic tests at Kenema Government Hospital in Sierra Leone. Lead researcher Matt Boisen and VHFC Director Robert F.

Publication - VHFC Investigators describe hypotheses of 'Emerging Diagnostics' in Science

In a recent paper in the magazine Science, VHFC researchers Pardis Sabeti and colleagues argue that many of the diseases labeled as 'emerging infectious diseases' are actually more an issue of 'emerging diagnostics'.

Publication – VHFC scientists describe the basis for the Lassa NP proteins exonuclease activity

In the August issue of PLoS One, VHFC research scientists from the Ollman Saphire lab at the Scripps Research Institute describe the molecular details of how the Lassa NP protein performs its nuclease activity. Digestion of viral RNA by this mechanisms appears to cause suppression of immune activity in infected cells and may be an important mediator of Lassa fever progression and disease.

Publication - Harvard researchers describe potential genetic resistance to Lassa

Rapidly evolving viruses and other pathogens can have an immense impact on human evolution as natural selection acts to increase the prevalence of genes providing resistance to disease. In their new paper, Andersen et al, provide evidence for two genes - IL21 and LARGE - as being targets of natural selection caused by Lassa virus.

Publication - Scripps Research Scientists Find Potential Achilles’ Heel on Lassa Fever

Scientists at The Scripps Research Institute have determined the atomic structure of a protein that the Lassa fever virus uses to make copies of itself within infected cells. The structural data reveal an unexpected molecular crevice where the viral protein grips the viral genes, making this crevice a target for potential antiviral drugs.

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