Publication - Structure of the Lassa virus nucleoprotein solved

The arenaviral nucleoprotein NP has been implicated in suppression of the host innate immune system, but the mechanism by which this occurs has remained elusive. In their paper published in the January 24th edition of PNAS, Dr. Ollmann-Saphire and her colleagues present the crystal structure at 1.5 Å of the immunosuppressive C-terminal portion of Lassa virus NP and illustrate that, unexpectedly, its 3D fold closely mimics that of the DEDDh family of exonucleases.

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