Publication - Harvard researchers describe potential genetic resistance to Lassa

Rapidly evolving viruses and other pathogens can have an immense impact on human evolution as natural selection acts to increase the prevalence of genes providing resistance to disease. In their new paper, Andersen et al, provide evidence for two genes - IL21 and LARGE - as being targets of natural selection caused by Lassa virus. This study gives insights into the host-pathogen evolution of Lassa and the human host and supports the hypothesis that selective pressures imposed by Lassa may have led to the emergence of particular alleles conferring resistance to Lassa fever opening up new avenues of research pursuit.

Read the paper for free in the current edition of Philosophical Transactions of the Royal Society B

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