Dr. Pardis Sabeti
Dr. Pardis C. Sabeti, MD, DPhil
FAS Center for Systems Biology
Department of Organismic and Evolutionary Biology
Harvard University Northwest Building, Room 469
52 Oxford Street
Cambridge, MA 02138
Pardis C. Sabeti is a Professor at the Center for Systems Biology at Harvard University, Department of Organismic and Evolutionary Biology, and an Associate Member of the Broad Institute. She graduated with an S.B. in Biology from MIT, an M.Sc. and D.Phil. from Oxford University, and an M.D. from Harvard Medical School, being the third woman ever to graduate summa cum laude.
Dr. Sabeti is an evolutionary geneticist with extensive expertise studying genetic diversity, developing algorithms to detect genetic signatures of natural selection, and carrying out genetic association studies. Her graduate work at Oxford University focused on host genetic factors in Plasmodium falciparum susceptibility and studying patterns of genetic diversity to identify rapidly evolving genes. At Harvard, she has developed novel methods to detect natural selection, and applied it to the entire human genome, finding many novel candidates.
Her lab focuses on detecting and characterizing signals of natural selection in humans and pathogens and has recently identified candidate genes associated with natural selection for Lassa Fever virus infection in populations in Nigeria, recently published in Nature. Pardis's awards and fellowships include the Rhodes Scholarship, the Soros Fellowship, L'Oreal For Women in Science Fellowship, the Damon Runyon Cancer Foundation Post-doctoral fellowship, the Burroughs Wellcome Career Award in Biomedical Sciences, and the Packard Foundation Fellowship for Science and Engineering. Pardis is also the lead singer and bassist of the alternative rock band Thousand Days.
- Integrating common and rare genetic variation in diverse human populations.
International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, et al.
Nature. 2010 Sep 2;467(7311):52-8.
- A composite of multiple signals distinguishes causal variants in regions of positive selection
Grossman SR, Shylakhter I, Karlsson EK, et al.
Science. 2010 Feb 12;327(5967):883-6. Epub 2010 Jan 7.
- Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.
Neafsey DE, Schaffner SF, Volkman SK, et al.
Genome Biol. 2008;9(12):R171. Epub 2008 Dec 15.
- Genome-wide detection and characterization of positive selection in human populations
Sabeti PC, et al.
Nature. 2007 Oct 18;449(7164):913-8.
- A genome-wide map of diversity in Plasmodium falciparum.
Volkman SK, Sabeti PC, DeCaprio D, et al.
Nat Genet. 2007 Jan;39(1):113-9. Epub 2006 Dec 10.
- Positive natural selection in the human lineage
Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES.
Science. 2006 Jun 16;312(5780):1614-20. Review.
- The case for selection at CCR5-Delta32
Sabeti PC, Walsh E, Schaffner SF, et al.
PLoS Biol. 2005 Nov;3(11):e378. Epub 2005 Nov 1.
- Detecting recent positive selection in the human genome from haplotype structure
Sabeti PC, Reich DE, Higgins JM, et al.
Nature. 2002 Oct 24;419(6909):832-7. Epub 2002 Oct 9.