Dr. Kristian G. Andersen
Dr. Kristian G. Andersen, Ph.D.
Director of Infectious Disease Genomics
The Scripps Research Institute
10550 North Torrey Pines Road, SGM-300A
Department of Immunology
La Jolla CA 92037
Originally from Denmark, Dr. Andersen received his Ph.D. from the University of Cambridge and the MRC Laboratory of Molecular Biology in 2009. He was the recipient of the Carlsberg Foundation PhD Scholarship from 2005-2008 and was awarded a postdoctoral fellowship from the same foundation in 2009 and 2010. In 2008 he was awarded the Max Perutz prize for "outstanding graduate research" at the University of Cambridge.
His research has spanned many research areas and disciplines. Using experimental animal models and molecular biological techniques, Dr. Andersen elucidated the evolutionary history of regulatory T cell-mediated tolerance mechanisms. He then exploited that knowledge to develop novel immune-based therapies and showed that they could be used for the treatment of arthritis, diabetes, and transplantation rejection in a number of different animal models.
Dr. Andersen's more recent research has focused on the complex relationship between host and pathogen. Using a combination of next-generation sequencing, experimentation and computational biology he has spearheaded large international collaborations investigating the spread and evolution of highly deadly pathogens, including Ebola virus and Lassa virus. This work provided insights into the emergence and transmission of Ebola virus during the 2013-2015 epidemic in West Africa, and formed the foundation for the usage of genomic tools during a rapidly evolving outbreak.
- Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, Phelan E, Tariyal R, Tewhey R, Omoniwa O, Fullah M, Fonnie R, Fonnie M, Kanneh L, Jalloh S, Gbakie M, Saffa S, Karbo K, Gladden AD, Qu J, Stremlau M, Nekoui M, Finucane HK, Tabrizi S, Vitti JJ, Birren B, Fitzgerald M, McCowan C, Ireland A, Berlin AM, Bochicchio J, Tazon-Vega B, Lennon NJ, Ryan EM, Bjornson Z, Milner DA Jr, Lukens AK, Broodie N, Rowland M, Heinrich M, Akdag M, Schieffelin JS, Levy D, Akpan H, Bausch DG, Rubins K, McCormick JB, Lander ES, Günther S, Hensley L, Okogbenin S; Viral Hemorrhagic Fever Consortium, Schaffner SF, Okokhere PO, Khan SH, Grant DS, Akpede GO, Asogun DA, Gnirke A, Levin JZ, Happi CT, Garry RF, Sabeti PC.
Cell. 2015 Aug 13;162(4):738-50.
- Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone
Park DJ, Dudas G, Wohl S, Goba A, Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J, Gire SK, Gladden-Young A, Jalloh S, Nosamiefan D, Yozwiak NL, Moses LM, Jiang PP, Lin AE, Schaffner SF, Bird B, Towner J, Mamoh M, Gbakie M, Kanneh L, Kargbo D, Massally JL, Kamara FK, Konuwa E, Sellu J, Jalloh AA, Mustapha I, Foday M, Yillah M, Erickson BR, Sealy T, Blau D, Paddock C, Brault A, Amman B, Basile J, Bearden S, Belser J, Bergeron E, Campbell S, Chakrabarti A, Dodd K, Flint M, Gibbons A, Goodman C, Klena J, McMullan L, Morgan L, Russell B, Salzer J, Sanchez A, Wang D, Jungreis I, Tomkins-Tinch C, Kislyuk A, Lin MF, Chapman S, MacInnis B, Matthews A, Bochicchio J, Hensley LE, Kuhn JH, Nusbaum C, Schieffelin JS, Birren BW, Forget M, Nichol ST, Palacios GF, Ndiaye D, Happi C, Gevao SM, Vandi MA, Kargbo B, Holmes EC, Bedford T, Gnirke A, Ströher U, Rambaut A, Garry RF, Sabeti PC.
Cell. 2015 Jun 18;161(7):1516-26.
- Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa
Stremlau MH, Andersen KG, Folarin OA, Grove JN, Odia I, Ehiane PE, Omoniwa O, Omoregie O, Jiang PP, Yozwiak NL, Matranga CB, Yang X, Gire SK, Winnicki S, Tariyal R, Schaffner SF, Okokhere PO, Okogbenin S, Akpede GO, Asogun DA, Agbonlahor DE, Walker PJ, Tesh RB, Levin JZ, Garry RF, Sabeti PC, Happi CT.
PLoS Negl Trop Dis. 2015 Mar 17;9(3):e0003631.
- Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC.
Science. 2014 Sep 12;345(6202):1369-72.
- Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples
Matranga CB, Andersen KG, Winnicki S, Busby M, Gladden AD, Tewhey R, Stremlau M, Berlin A, Gire SK, England E, Moses LM, Mikkelsen TS, Odia I, Ehiane PE, Folarin O, Goba A, Kahn SH, Grant DS, Honko A, Hensley L, Happi C, Garry RF, Malboeuf CM, Birren BW, Gnirke A, Levin JZ, Sabeti PC.
Genome Biol. 2014;15(11):519.
- Clinical illness and outcomes in patients with Ebola in Sierra Leone
Schieffelin JS, Shaffer JG, Goba A, Gbakie M, Gire SK, Colubri A, Sealfon RS, Kanneh L, Moigboi A, Momoh M, Fullah M, Moses LM, Brown BL, Andersen KG, Winnicki S, Schaffner SF, Park DJ, Yozwiak NL, Jiang PP, Kargbo D, Jalloh S, Fonnie M, Sinnah V, French I, Kovoma A, Kamara FK, Tucker V, Konuwa E, Sellu J, Mustapha I, Foday M, Yillah M, Kanneh F, Saffa S, Massally JL, Boisen ML, Branco LM, Vandi MA, Grant DS, Happi C, Gevao SM, Fletcher TE, Fowler RA, Bausch DG, Sabeti PC, Khan SH, Garry RF; KGH Lassa Fever Program; Viral Hemorrhagic Fever Consortium; WHO Clinical Response Team.
N Engl J Med. 2014 Nov 27;371(22):2092-100.
- Identifying recent adaptations in large-scale genomic data
Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RN, Hill AV, Vannberg FO, Rinn JL; 1000 Genomes Project, Lander ES, Schaffner SF, Sabeti PC.
Cell. 2013 Feb 14;152(4):703-13.
- Epidemiology. Emerging disease or diagnosis?
Gire SK, Stremlau M, Andersen KG, Schaffner SF, Bjornson Z, Rubins K, Hensley L, McCormick JB, Lander ES, Garry RF, Happi C, Sabeti PC.
Science. 2012 Nov 9;338(6108):750-2.
- Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution
Andersen KG, Nissen JK, Betz AG.
Front Immunol. 2012 May 10;3:113.
- Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever
Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC
Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77
- Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells
Andersen KG, Butcher T, Betz AG
PLoS Biol. 2008 Nov 11;6(11):e276
- Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
Sarris M, Andersen KG, Randow F, Mayr L, Betz AG
Immunity. 2008 Mar;28(3):402-13. Epub 2008 Mar 6
- Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus
Kallikourdis M, Andersen KG, Welch KA, Betz AG
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):594-9